Immune System

We develop organic or conventional based on the client specifications. We source both plant and animal-based ingredients to formulate immune health supplements. Oral supplement formulation improves the systemic and local immune response.

Our expertise develops formulations using plant extracts (e.g., Sambucus nigra SN), spices (e.g., curcumin from turmeric, capsaicin from red pepper, piperine from black pepper, eugenol from cloves, allyl sulfides from garlic and onion), bioactive lipids (Omega 3 fatty acids), and nutraceuticals (tocopherols, gamma oryzanol, sesame lignans, polyphenols carotenoids) for enhancing resistance and recover from SARS-CoV-2, COVID, SARS, MERS infection.

We also extract dietary polyphenolic compounds and flavonoids (litchi seeds, Kaempferol, quercetin, olives, litchi seeds, honey, berries, raspberry) and their compounds (gallic acid, ellagic acid, cinnamic acid, benzoic acid, caffeic acid, coumaric acid, apigenin, myricetin, quercetin, catechin, naringenin, and luteolin) which are effective inhibitors of COVID-19 main protease.

Other foods that are rich in Vitamin A (retinol), vitamin C (ascorbic acid), Vitamin D (ergocalciferol), Zinc and Selenium, and Vitamin E (alpha-tocopherol), Vitamin B6, Folate, Lactobacillus, probiotics also incorporated in nutraceutical formulations. Besides, we also extract active ingredients from carrot, spinach, and sweet potato. All the above compounds not only possess immune-boosting ingredients but also antioxidant, anti-inflammatory, anti-bacterial, antiviral, anti-tumour, phytochemical, vasodilative and antimicrobial activity.

Protein imbalances also lead to malnutrition resulting in impaired immunity. Studies have shown that artificially altered milk proteins such as serum albumin, β-lactoglobulin, and α lactalbumin act on viruses and inhibit viral absorption and thereby replication. Our scientists can formulate products incorporating milk proteins.

Evidence has shown that a plant-based diet is effective in reducing the risks of influenza and pneumonia as these are rich in dietary fibre, antioxidants and vitamins, which lower BMI and thereby help in improving immunity. At FRL FRL, we can develop functional foods that contain supplements such as oats, fibre-enriched vermicelli, or wholesome natural foods, as well as modified foods that can be fortified with vitamins, minerals and probiotics.

The role of probiotics in preventing upper respiratory infections has been studied extensively. At FRL’s food research lab, we formulate probiotic supplements based on the specific requirement of the clients. We can incorporate probiotics into the diet in the form of yoghurt (e.g., with lactobacillus delbrukckiis sp. Bulgaricus, Lactiplantibacillus plantarum or Lactiplantibacillus reuteri ), bread, sourdough, tempeh, bread, kombucha, cottage, cheese, fermented sauerkraut, fermented pickle, miso soup, and kimchi.

The formulation depends on the requirements and classifies them. For instance, we extract chemical constituents (active ingredients) such as nutrients and herbals [(e.g., Polysaccharides can be extracted from different plants such as Silybum marianum L. (milk thistle)], phytochemicals, polyunsaturated fatty acids, or extract probiotics, and prebiotics or nutraceutical enzymes. We also carry out formulation in non-traditional forms by fortification or recombinant nutraceuticals.

We can formulate the products in the form of soft or hard gels, capsules, tablets, syrups, gummies, or sachets containing a concentrated source of minerals, vitamins, or botanical extracts

FRL's scientists and formulation experts identify new delivery mechanisms (such as liposomes) and research-active compounds to develop a highly functional immune booster product that provides the intended results. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

Any ingredient incorporated into the formulation needs to achieve its intended function in the human body at the same time, must adhere to safety guidelines. At FRL, we substantiate this from many different types of investigation, including secondary research for existing ingredients or, if it's novel, publishing the work in reputable, peer-reviewed journals. Data for this will be derived from chemical comparisons and analysis, activities (e.g., ORAC or oxygen radical absorbance activities), testing in animal models, genomic/gene expression studies, in vitro bioassays and, most compelling of all, human clinical testing. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

We follow quality measures to ensure the products are safe from both the supplier and the buyer's perspectives. We carry out Marker Chemistry (e.g., HPLC, GC etc.), Microbiology tests (e.g., Pseudomonas, Salmonella, Escherichia Coli), heavy metal analysis (e.g., lead, arsenic, cadmium kept below the regulatory limits), Contamination (e.g., metal flakes from machinery), physical characteristics (e.g., powders for tablets must have low moisture content) and stability (e.g., the time for a product from initial production). We use compendium methods (USP and European Pharmacopeia) for an extensive validation process.

We follow a specific set of regulations that a product must adhere to. This includes manufacturing flow chart, solvents, quantitative ingredient lists, physical characteristics, GMO status, certifications, radiations, pesticide/chemical/ residue, contaminants, microbiology, allergens, animal derivation, and safety (Standard Material Safety Data Sheet – toxicity or clinical testing). We assist ensure to clear the ingredient supplier completes clearance through the target country’s regulatory agency prior to its inclusion in formulas. Through our years of experience, our team can speed up the acceptance and inclusion of new material. Our product development team complies with the Food, Drug and Cosmetics Act (FDA 2009), DSHEA and the Fair Packaging and Labeling Act (Federal Trade Commission 2011), safety and quality food and food supplements guidelines delineated by WHO and the United Nations Food and Agricultural Organization (FAO). Our team ensures to use only acceptable ingredients that are found in the International Nomenclature. We also adhere to the local country’s guidelines as per the client’s request, such as for the Japanese Ministry of Health, Labor and Welfare (MHLW), The Chinese Health Care Association (CHCA), China’s State Food and Drug Administration (SFDA) and FSSAI.