Bone and Joint Health

We develop organic or conventional based on the client specifications. We source both plant and animal-based ingredients to formulate bone and joint health.

We use safe, inexpensive and proven ingredients from natural sources that exhibit anti-osteoclastogenesis potential. Example 1-acetooxychavicol acetate from Apina galangal, acetyl-11-keto-beta-boswellic acid (salai guggul), butein (Cashew), curcumin and calebin A (from turmeric), cardamonin (from Cardamonin), coronarin D (White ginger lily), disegenin (from fenugreek), embelin (false black pepper), gambogic acid (from mangosteem), gossypin (rose mallow), guggulsterone (guggle tree), honokiol (hou po), isodexoyelephantopin (elephant foot), indole-3 carbinol (brassica species), plumbagin (from chitrak), reseveratrol (from grapes), simvastatin, thiocolchicoside from flame lily, withanolides (from ashwagandha), zerumbone (subtropical ginger), and zyflamend (poly herbal)

The nutraceuticals identified from dietary agents such as butein, cardamonin, coronarin D curcumin, diosgenin, embelin, gambogic acid, genistein, plumbagin, quercetin, reseveratrol, zerumbone and more, can modulate cell signaling pathways and reverse/slow down osteoporosis.

The formulation depends on the requirements and classifies them. For instance, we extract chemical constituents (active ingredients) such as nutrients and herbals [(e.g., Polysaccharides can be extracted from different plants such as Silybum marianum L. (milk thistle)], phytochemicals, polyunsaturated fatty acids, or extract probiotics, and prebiotics or nutraceutical enzymes. We also carry out formulation in non-traditional forms by fortification or recombinant nutraceuticals.

We can formulate the products in the form of ready-to-drink, ready-to-serve, ready-to-eat, ready-to-cook, ready-to-drink, ready-to-mix formulations along with soft or hard gels, capsules, tablets, syrups, gummies, or sachets containing a concentrated source of minerals, vitamins, or botanical extracts

We can fortify the foods with Calcium, Vitamin D, Magnesium, Vitamin C, Vitamin B12, zinc, Vitamin E, and Vitamin K, along with enhancers such as inulin or whey protein. Polyphenols, and lycopene, have also been used in the formulations. We can also formulate food using food waste such as chicken eggshells, duck eggshells, quail eggshells, seashells, oyster shells, and fish bones.

We can enhance biscuits, bread, breaded fried meat, pizza, spaghetti, chocolate cake, muffin, Nham, Ser Smazony, white bread, yoghurt, and pasta by incorporating shells from the various sources.

Herbal-based formulation

Our Scientists formulate herbal-based formulations by utilizing Isoflavones, soybean, red clover, alfalfa, Pueraria candollei var. mirifica, epimedium, hop, dried plums, horsetail, salvia miltiorrhiza, labisia pumila and eurycoma longifolia, drynaria fortunei, tea, broccoli,

Dairy-based beverages formulation

We formulate the functional dairy-based beverages

Functional dairy-based beverages can be divided into two main groups:

• Formulation of Added-value dairy beverages: this category includes those beverages in which one or more components have been removed, for example, lactose-free milk, low-fat milk, or low-fat drinkable yoghurt.
• Formulation of Fortified dairy beverages: fortification increases the amount of nutrients commonly present before processing in a food product. This is the case with calcium, magnesium, conjugated linoleic acid (CLA), whey proteins (WPs), or fat-soluble vitamins such as A or D.
• Formulation of Enriched dairy beverages: this category encompasses dairy beverages to which bioactive component has been added to promote health benefits beyond their basic nutritional value, for example, probiotics, prebiotics, phytochemicals, fiber, sterols, or omega-3-enriched dairy beverages, among others.

Pro-prebiotic formulations for bone health

Functional dairy-based beverages enriched in probiotics are an optimum way to reestablish the intestinal microflora balance. Our formulation experts ensure that the probiotics (e.g., Lactobacillus acidophilus (L. acidophilus) and Bifidobacterium animalis subsp. Lactis) comply with neutral pH, total solids level, absence of oxygen, and near ambient temperatures. Probiotic drinking yoghurt with L Casei Imunitass cultures, B Longum BB536, S Thermophilus, L delbrueckii subsp bulgaricus, milk drink containing Lactobacillus Casei Shirota Drink yoghurt with LGG, vitamins and minerals. Our food experts ensure the stability of these formulations and ensure the protection of functional ingredients within edible delivery methods.

The phytosterols-based formulation for bone health

The intake of 2–3g/day of phytosterols is associated with a significant lowering (5%–15% range) of LDL (LDL-cholesterol) (MacKay and Jones, 2011). The European Food Safety Authority (EFSA) and the Food and Drug Administration (FDA) approved the health claim related to plant sterols and plant stanols and maintenance of normal blood cholesterol concentrations (EFSA journal numbers 2010;8(10):1813 and 2011;9(6):2203 and FDA 21 CFR 101.83, respectively).However, the current intake ranges between 150-400 mg/d, which supposes about 10% - 20% of the recommended intake. We formulate products based on phytosterols such as synthesized from vegetable oil, for example, sunflower oil or soybean oil. Among dairy, spreads were the first commercial applications of plant sterols-enriched food, and low-fat milk and reduced-fat yoghurt are the most commercialized functional dairy-based beverages enriched in plant sterols

Skimmed Cow’s milk with plant sterol esters (e.g. Floral ProActive), skimmed fermented milk with plant sterol (e.g. Danacol), Yoghurt drink with plant sterols (e.g. Kaiku Benecol), Milk with plant sterol

Vitamins and Minerals formulation for bone and joint health

FRL's scientific expertise can fortify milk with calcium lactate gluconate, tricalcium citrate M1098, trimagensium citrate, xnhydros, and for yoghurt, zinc citrate, tricalcium citrate, trimagnesium citrate nonahydrate and zinc citrate.

Fibre enriched beverages formulation

We can formulate flavoured milk fortified with fiber, frutoologasaccharides (e.g. Ensure Plus Fibre), high fibre drinkable yoghurt (e.g. Fruzinga High fibre drinkable yoghurt), milk with fibre (e.g. Milk fibra con regulaplus)

Omega 3 enriched drinks

Formulation of milk fortified with omega 3 from flaxseed oils, milk with nuts fortified in omega 3 and oleic acid, and milk fortified in omega 3 (e.g. Natrel, Puleva, Dukat) are possible with FRL’s FRL expertise

Vitamins and Minerals enrichment

Our expertise can formulate Milk enriched with 22 vitamins and minerals, including folic acid, milk fortified with proteins and vitamins, fermented milk drink enriched in magnesium, lactose-free milk enriched in calcium, banana-flavoured yoghurt enriched with vitamin D (e.g., Valioyoghurtti)

Protein-enriched formulation

Our expertise can formulate yoghurt and juice with low sugar beverages enriched in proteins milk concentrate (e.g., Yoplait), flavoured yoghurt shakes with protein and fibre milk protein concentrate and polydextrose, flavored milk smoothie with protein Kefir and probiotics, flavored water with whey protein, fermented milk enriched in bioactive peptides. Flavored milk smoothie with protein kefir and probiotics, flavored water with whey protein, and fermented milk enriched in bioactive peptides.

Phytochemicals based formulation

Our expertise are experts in Milk with Mobilee, an extract rich in hyaluronic acid, polysaccharides and collagen (Atricular dairy drink), milk with turmeric acid (Turmeric Milk), flavored milkshakes with haldi extract (0.05%), drinkable aloe yoghurt, skimmed and semi-skimmed milk enriched in calcium (160mg/100mL) and isoflavones from soya (0.01%, 10mg/100mL)

FRL's scientists and formulation experts identify new delivery mechanisms (such as liposomes) and research-active compounds to develop a highly functional bone strength product that provides the intended results. Our formulation experts ensure that the end product would meet the required pH, dispersibility, efficacious dosage, mouthfeel, flavour, odor and taste. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

Any ingredient incorporated into the formulation needs to achieve its intended function in the human body at the same time, must adhere to safety guidelines. At FRL, we substantiate this from many different types of investigation, including secondary research for existing ingredients or, if it's novel, publishing the work in reputable, peer-reviewed journals. Data for this will be derived from chemical comparisons and analysis, activities (e.g., ORAC or oxygen radical absorbance activities), testing in animal models, genomic/gene expression studies, in vitro bioassays and, most compelling of all, human clinical testing. Through years of expertise and knowledge, we bring in the right solutions that fit your requirements.

We follow quality measures to ensure the products are safe from both the supplier and the buyer's perspectives. We carry out Marker Chemistry (e.g., HPLC, GC etc.), Microbiology tests (e.g., Pseudomonas, Salmonella, Escherichia Coli), heavy metal analysis (e.g., lead, arsenic, cadmium kept below the regulatory limits), Contamination (e.g., metal flakes from machinery), physical characteristics (e.g., powders for tablets must have low moisture content) and stability (e.g., the time for a product from initial production). We use compendium methods (USP and European Pharmacopeia) for an extensive validation process.

We follow a specific set of regulations that a product must adhere to. This includes manufacturing flow chart, solvents, quantitative ingredient lists, physical characteristics, GMO status, certifications, radiations, pesticide/chemical/ residue, contaminants, microbiology, allergens, animal derivation, and safety (Standard Material Safety Data Sheet – toxicity or clinical testing). We assist ensure to clear the ingredient supplier completes clearance through the target country’s regulatory agency prior to its inclusion in formulas. Through our years of experience, our team can speed up the acceptance and inclusion of new material. Our product development team complies with the Food, Drug and Cosmetics Act (FDA 2009), DSHEA and the Fair Packaging and Labeling Act (Federal Trade Commission 2011), safety and quality food and food supplements guidelines delineated by WHO and the United Nations Food and Agricultural Organization (FAO). Our team ensures to use only acceptable ingredients that are found in the International Nomenclature. We also adhere to the local country’s guidelines as per the client’s request, such as for the Japanese Ministry of Health, Labor and Welfare (MHLW), The Chinese Health Care Association (CHCA), China’s State Food and Drug Administration (SFDA) and FSSAI.