Why Choose Food Research Lab's FRL as Your Food Product Development (FPD) Consultant and Partner?

There are several options in almost every product area in today’s market, and the difficulty is in coming up with unique items that stand out and connect with customers. Food Research Lab's Food Research Lab takes a holistic approach to creating food and beverage products. We define, demographically target, and build effective goods through a sequential process for category selection and comprehension. The client can visit the lab to learn the process. We offer unlimited rounds of revisions to ensure customer satisfaction. The final product prototype, along with the documentation process, including the video (through email), will be shipped to the client, and in case the client is not satisfied with the video, a food technology consultant will visit the place for the product demo at the client’s costs.

What are the different forms that you deliver the Food Product Formulations?

The food industry is witnessing a new form of consumption. Keeping that in mind, we can formulate the products in the form of ready-to-eat, ready-to-drink, ready-to-mix, ready-to-serve, and ready-to-cook food products. We use ingredients that offer an added value to the development and improve its indulgence and sustainability in terms of its functional ingredients, plant-based food dyes, and natural preservatives with a clean label.

What are the sectors Food Research Lab cover?

We cover a wide range of sectors such as soups, sauces and dips, chips, tortillas, dry beverage powder, plant-based products, masalas, puddings, instant mixes and many more.

How is sensory testing been carried out?

Our sensory examination leads to the precise formulation and recipe recommendations. We develop data-driven design models based on sensory research and customer insights. The fact-based design methodology used by Food Research Lab reduces risk and gives our clients market confidence while cutting development time in half. With our dedicated sensory lab facility, our team takes satisfaction in creating and optimizing successful products in the marketplace, generating a favourable return on investment, and developing brand advocates.

The widespread use of antibiotics and environmental shifts have significantly impacted gut microbial diversity, increasing susceptibility to infections by drug-resistant pathogens. As antimicrobial resistance (AMR) continues to pose a public health challenge, recent studies highlight probiotics and prebiotics as potential interventions to restore gut microbiota and reduce pathogen colonization.

The Role of Probiotics and Prebiotics in Decolonizing Pathogenic Bacteria: Evidence-Based Insights

Interesting News . Dec 27, 2024

The widespread use of antibiotics and environmental shifts have significantly impacted gut microbial diversity, increasing susceptibility to infections by drug-resistant pathogens. As antimicrobial resistance (AMR) continues to pose a public health challenge, recent studies highlight probiotics and prebiotics as potential interventions to restore gut microbiota and reduce pathogen colonization.

A 2024 systematic review and meta-analysis published in Gut Microbes by Rahman and co-authors assessed the efficacy of probiotics and prebiotics in decolonizing AMR pathogens in human and animal studies. Here’s a summary of the findings and their implications for product development in the nutraceutical and functional food sectors.

Key Findings from the Meta-Analysis

Individuals with severe health conditions such as acute pancreatitis, inflammatory bowel disease, liver disease, or HIV are advised to consult healthcare professionals before probiotic supplementation.

Probiotic Efficacy
- Decolonization Rates:
  - Persistence of pathogenic bacteria was significantly lower in the probiotic group (22%) compared to placebo (30.8%).
  - The pooled odds ratio for decolonization favored probiotics (OR: 0.59; 95% CI: 0.43–0.81; p = 0.0001) with moderate certainty.
- Pathogen-Specific Results:
  - Clostridioides difficile (C. difficile): Highest decolonization rate at 82.4%.
  - Lactobacillus-based Probiotics: Decolonized 71% of pathogens.
  - Saccharomyces boulardii: Achieved 77% decolonization.
- Subgroup Analysis:
  - Types of probiotics and pathogens significantly moderated outcomes (p < 0.02).
  - Dosage and geographic regions showed no significant impact (p > 0.05).
Prebiotic Effectiveness
- Prebiotics reduced pathogen load by 30% to 80% through modulation of gut microbial diversity.
- Evidence suggests prebiotics enhance the colonization resistance of the gut microbiome.
Evidence Strength and Limitations
- The analysis reported moderate certainty for probiotics and prebiotics in decolonizing pathogens.
- Further clinical studies focusing on specific strains are needed to validate these findings.

This graph highlights:

Implications for Manufacturers

Opportunities for Innovation

Manufacturers in the nutraceutical and functional food industries can leverage these findings to:

Consumer-Focused Product Development
The evidence supports the development of products aimed at:
- The evidence supports the development of products aimed at:
- AMR pathogen management in at-risk populations.
Regulatory Compliance and Claims
- Highlight specific health benefits such as reducing pathogen colonization and enhancing gut diversity.
- Ensure formulations comply with regulatory standards, such as FSSAI, FDA, or EFSA.

How FRL Can Help

At Food Research Lab, we specialize in helping manufacturers translate evidence-based insights into market-ready products. Here’s how we can assist:

Product Formulation
- Customized Probiotics: Develop formulations using evidence-backed strains like Lactobacillus and Saccharomyces boulardii.
- Synergistic Prebiotic Solutions: Create blends that enhance probiotic efficacy and gut health.
Clinical Validation
- Conduct or manage clinical trials to substantiate claims of pathogen decolonization and microbiome restoration.
Regulatory Support
- Prepare dossiers and documentation to meet global regulatory standards.
- Assist in labeling and claims validation to ensure compliance.
Market Positioning
- Provide scientific data and educational materials to differentiate your products in a competitive market.
- Offer guidance on branding and consumer-targeted messaging.

Level Q: Quantitative Evidence

This meta-analysis provides Level Q evidence, meaning:

It is derived from randomized controlled trials (RCTs), the gold standard for clinical research.
The meta-analysis used robust statistical tools like the random-effects model and GRADE framework to assess evidence certainty.
Findings, such as the pooled odds ratio (OR: 0.59; CI: 0.43–0.81) for probiotics, indicate moderate certainty with statistical significance (p = 0.0001).

Level B: Evidence from Subgroup Analysis

The study conducted subgroup analyses for:

Pathogen Types (e.g., C. difficile showed 82.4% decolonization).
Probiotic Types (e.g., Lactobacillus-based probiotics and Saccharomyces boulardii decolonized 71% and 77%, respectively).
These analyses provide Level B evidence, highlighting reliable but slightly less generalizable findings due to specific subgroup focus.

Certainty and Applicability

Implications for Manufacturers

The levels of evidence support the development of targeted probiotic formulations:

Conclusion

Probiotics and prebiotics show promising potential in managing AMR pathogens by restoring gut microbial diversity and enhancing colonization resistance. Manufacturers can capitalize on these findings to develop innovative, evidence-backed products that meet the growing demand for functional gut health solutions.

FRL can assist in designing formulations and conducting additional clinical trials to upgrade these levels to Level A (high confidence) through larger, more focused studies. Contact us to align your product development with the latest evidence. Contact FRL to turn this evidence into action and create products that not only support gut health but also tackle global health challenges like antimicrobial resistance.