At FRL, we specialize in providing complete solutions for glucosyl hesperidin, an EFSA-approved novel food ingredient that is revolutionizing both the nutraceutical and skincare industries. Our services go beyond sourcing and selling—we offer expert guidance on how to incorporate this powerful bioflavonoid into your formulations and provide support throughout the manufacturing process. Whether you're developing functional foods, beverages, or beauty products, FRL is your trusted partner.
The European Food Safety Authority (EFSA)2015/2283 has approved glucosyl hesperidin as a novel food ingredient, paving the way for its use in nutraceuticals, expanding its role beyond skincare.
At FRL, we specialize in providing complete solutions for glucosyl hesperidin, an EFSA-approved novel food ingredient that is revolutionizing both the nutraceutical and skincare industries. Our services go beyond sourcing and selling—we offer expert guidance on how to incorporate this powerful bioflavonoid into your formulations and provide support throughout the manufacturing process. Whether you're developing functional foods, beverages, or beauty products, FRL is your trusted partner.
Glucosyl hesperidin (also known as alpha-glucosyl hesperidin or AGH) is a bioflavonoid derived from citrus fruits that has been enzymatically modified to enhance its bioavailability. Hesperidin was first isolated in 1828 by French chemist Lebreton from the albedo, the porous inner layer of orange peel. Since then, it has also been found in lemons and other citrus fruits. The name “hesperidin” is derived from “hesperidium,” a term used to describe the fruit of citrus trees. In recent years, hesperidin has gained increased attention in the medical field, with a growing focus on scientific research. This unique modification has opened new doors for its application in food, beverages, and nutraceuticals. The following Table 1 provides the chemical identity of α-Monoglucosyl Hesperidin (MGH)
Chemical Identity of α-Monoglucosyl Hesperidin (MGH)
| -Monoglucosyl Hesperidin (MGH) | Details |
| Chemical Substance | α-Monoglucosyl Hesperidin (MGH) |
| Chemical (IUPAC) Name | (2S)-7 -[(O-6-Deoxy-α-l-mannopyranosyl-(1→6)-O-[α-d-glucopyranosyl-(1→4)]-β-d-glucopyranosyl)oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one |
| Common Name | Glucosyl hesperidin |
| Synonyms | 4G-α-d-glucopyranosyl-hesperidin; alpha-glucosyl-hesperidin; enzymatically modified hesperidin; monoglucosyl hesperidin |
| Abbreviations | α-GH; GH; MGH |
| Trade Names | Hayashibara Hesperidin S; CitraPeak |
| CAS Number | 161713–86-6 |
| Molecular Formula | C34H44O20 |
| Molecular Weight | 772.70 Da |
2. Why Should Manufacturers Consider Glucosyl Hesperidin?
Key Benefits for Nutraceutical Products
AGH offers several functional health benefits, including cardiovascular, anti-diabetic, and anti-inflammatory properties (2). These make it an ideal candidate for inclusion in health supplements targeting stress relief, heart health, and metabolic support as shown in the Figure 1.
What makes glucosyl hesperidin superior to standard hesperidin?
The enzymatic bonding of glucose to hesperidin significantly improves water solubility, making it easier for the body to absorb, thus enhancing its effectiveness in nutraceutical formulations.
3. EFSA’s Approval: Safety and Regulatory Compliance (3)
Ensuring Safety in Nutraceutical Formulations
In 2024, the European Food Safety Authority (EFSA) approved glucosyl hesperidin for use in food and beverage products at levels up to 364 mg per day for adults. Extensive safety evaluations, including a 90-day toxicity study, confirmed its safety for human consumption.
Is glucosyl hesperidin safe for human consumption?
Yes, EFSA concluded that AGH poses no safety concerns, including genotoxicity risks, and set a No Observed Adverse Effect Level (NOAEL) of 1,000 mg/kg of body weight per day.
4. Application in Food and Beverage Manufacturing
Versatility in Product Development
AGH’s improved solubility and neutral taste make it highly versatile for use in various nutraceutical formulations, including hot beverages, non-alcoholic drinks, confectioneries, and dietary supplements.
How can glucosyl hesperidin be used in nutraceutical formulations?
It can be incorporated into a wide range of products like hot drinks, energy drinks, and supplements, where its health benefits and enhanced bioavailability offer significant consumer appeal. The proposed and maximum uses levels (mg/NF/L or mg NF/day) are reported in the following table 2.
| FoodEx2 Level | FoodEx2 Code | Food Category | Maximum Use Level |
| Food supplements | — | — | 200 mg/day for general population older than 10 years |
| — | — | 115 mg/day for children aged 3 to 10 years | |
| — | — | 60 mg/day for young children aged 1 to 3 years | |
| L3 | A03FZ | Functional drinksa | 525 mg/L |
Energy drinks, isotonic drinks, and sports drink and fermented functional drink (fermented non-alcoholic drinks with exclusion of dairy fermented drinks)
5. Functional Benefits for Nutraceuticals
Health-Boosting Properties
Glucosyl hesperidin is known for its stress-relieving properties and support for cardiovascular health, among other benefits. This makes it an ideal ingredient for products aimed at improving overall well-being.
Additionally, glucosyl hesperidin can create a moisture-locking barrier on the skin, making it particularly useful in colder environments where it provides long-lasting hydration. This property enhances its potential for nutraceutical formulations designed to support skin health and hydration from within.
What health benefits does glucosyl hesperidin provide? (2)
AGH offers cardiovascular, anti-inflammatory, and anti-diabetic benefits, along with potential stress relief, making it suitable for formulations targeting heart health, metabolic function, and stress management.
6. Sustainability and Sourcing of Glucosyl Hesperidin
Eco-Friendly Production
One of the standout features of AGH is its potential for sustainable production. It can be made from upcycled citrus by-products, reducing waste and enhancing sustainability credentials for manufacturers.
How can manufacturers source sustainable glucosyl hesperidin?
AGH can be sourced from repurposed citrus fruits, such as those removed during harvest or unsellable produce, offering an eco-friendlier approach to ingredient sourcing.
7. Market Trends and Consumer Appeal
• Meeting Consumer Demand for Health and Sustainability
As consumers increasingly seek health-boosting ingredients and eco-friendly products, glucosyl hesperidin offers manufacturers a unique opportunity to tap into these growing market trends.
What consumer trends support the use of glucosyl hesperidin?
Yes, EFSA concluded that AGH poses no safety concerns, including genotoxicity risks, and set a No Observed Adverse Effect Level (NOAEL) of 1,000 mg/kg of body weight per day.
8. Practical Considerations for Formulation
Practical Considerations for Formulation
When formulating with glucosyl hesperidin, manufacturers should consider factors like solubility, dosage levels, and the stability of the ingredient in different product formats.
What should manufacturers know when adding glucosyl hesperidin to their products?
AGH is water-soluble and easy to incorporate into various products, but the recommended dosage must be adhered to, and its stability in different formulations should be tested during product development.
At FRL, we incorporate glucosyl hesperidin into our formulations to ensure optimal safety and effective dosages. This innovative approach not only enhances product performance but also aligns with industry standards. Contact us; by partnering with ingredient suppliers, we aim to create interest in this powerful ingredient, offering a unique selling point for nutraceutical and health-focused products.
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